Hydrobiome Serum

Epicutis Hydrobiome Serum
Balance, Calm, Strengthen
Meet the daily serum for skin that’s had enough. The Epicutis Hydrobiome Serum is a lightweight, fast-absorbing treatment that balances your microbiome, calms visible redness and reinforces your skin barrier, bringing stressed, reactive skin back to a calmer, healthier baseline. With just 10 ingredients and no fragrance, it’s a clean, clinically driven formula that fits easily into even the most sensitive routine.

At its heart is TCP, a patented TLR2 modulator developed by Signum Biosciences. TCP works with your skin’s microbiome to calm visible irritation and the inflammation linked to acne-causing bacteria (C. acnes), while supporting the beneficial flora healthy skin depends on. It’s paired with TPNa, a next-generation, water-soluble form of Vitamin E that delivers antioxidant protection and strengthens the barrier.

Sodium Hyaluronate instantly boosts moisture, while Propanediol adds plumping hydration and antimicrobial support, all in a silky gel that sinks in without residue.

The result? Skin that looks clearer, calmer and more resilient. It’s ideal for redness-prone and sensitive skin, for supporting inflamed breakouts alongside your acne routine, and for post-treatment recovery.

Key Benefits

• Balances the skin’s microbiome
• Calms visible redness, irritation and inflammation
• Strengthens and supports a compromised skin barrier
• Delivers antioxidant protection against environmental stress
• Boosts hydration with a lightweight, fast-absorbing feel

How to Use
Apply two pumps to clean fingertips and gently spread over the face until fully absorbed. Use one additional pump for the neck and décolleté. Use morning and night, then follow with your moisturizer. Pairs beautifully with Epicutis Hydrobiome Mist: mist first, then apply the serum.

Star Ingredients

• TCP – patented TLR2 modulator that calms inflammation and supports a balanced microbiome
• TPNa – water-soluble Vitamin E for antioxidant protection and barrier strength
• Sodium Hyaluronate – instantly boosts and holds moisture
• Propanediol – plumping hydration with antimicrobial benefits
• Glycerin – draws in lasting hydration and supports barrier function

Ideal For

• Redness, irritation or reactive skin
• Inflamed, acne-prone skin (alongside your acne routine)
• Compromised or damaged barriers
• Dehydrated skin
• Post-treatment care after facials, microneedling or laser

The Result
Calm, balanced, hydrated skin with a stronger barrier. This is your microbiome, supported and back to baseline.